The dipeptide alanyl-glutamine ameliorates peritoneal fibrosis and attenuates IL-17 dependent pathways during peritoneal dialysis
نویسندگان
چکیده
منابع مشابه
Peritoneal Dialysis
La,dialyse peritoneale constitue une methode d,epuration extra-renale simple,efficqCe et d,un prix de revient modere. La dialyse peritoneale,ne necestite aueuneinstalation complexe,peut-etre consideree comme une methode de reanimation non specialisedont la vulgarosation doit permettre: De traiter surplace d,une maniere intensive et prophylactique les nombreuses insuffisances renales aiPue...
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Peritoneal fibrosis is a major complication in peritoneal dialysis (PD) patients, which leads to dialysis discontinuation. Periostin, increased by transforming growth factor β1 (TGF-β1) stimulation, induces the expression of extracellular matrix (ECM) genes. Aberrant periostin expression has been demonstrated to be associated with PD-related peritoneal fibrosis. Therefore, the effect of periost...
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Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guide the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD.We therefore subj...
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Transforming growth factor beta (TGF-beta) plays a critical role in the pathogenesis of the peritoneal fibrosis that complicates long-term peritoneal dialysis (PD). We studied the TGF-beta/Smad signaling pathway in peritoneal fibrosis induced in uremic rats treated with PD and explored the therapeutic potential of Smad7 to prevent fibrogenesis. After subtotal nephrectomy, uremic rats were treat...
متن کاملOutput of peritoneal cells during peritoneal dialysis.
Peritoneal dialysis provides a good source for the collection of macrophages. Six patients with chronic renal failure undergoing peritoneal dialysis for the first time were studied, and maximum cell egress, mostly macrophages, occurred at 24-48 hours and diminished after 48 hours.
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ژورنال
عنوان ژورنال: Kidney International
سال: 2016
ISSN: 0085-2538
DOI: 10.1016/j.kint.2015.12.005